Defeat mutant KRAS with synthetic lethality
نویسندگان
چکیده
منابع مشابه
Defeat mutant KRAS with synthetic lethality
Ras proteins are considered as the founding members of a large superfamily of small GTPases that control fundamental cellular functions. Mutationally activated RAS genes were discovered in human cancer cells more than 3 decades ago, but intensive efforts on Ras structure, biochemistry, function and signaling continue even now. Because mutant Ras proteins are inherently difficult to inhibit and ...
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ژورنال
عنوان ژورنال: Small GTPases
سال: 2016
ISSN: 2154-1248,2154-1256
DOI: 10.1080/21541248.2016.1213783